Let’s Examine the Ingredients:

Korean Mistletoe:

Korean Mistletoe is a semi-parasitic plant that grows on various trees and has been used for centuries to treat a variety of ailments. It has been researched for a diverse range of potential benefits and is believed to have immunostimulatory, anti-diabetic, and anti-obesity properties, and much more. Of particular interest to athletes and fitness enthusiasts is that Korean Mistletoe has been reported to increase lean muscle mass, strength, and overall exercise capacity.

Recent research has focused on Korean Mistletoe Extract for use as a treatment for the prevention and reversal of muscle wasting conditions. The research on Korean Mistletoe Extract has been exceptional and could be quite beneficial for athletes. It has been shown to regulate gene expression related to muscle atrophy (muscle breakdown) and muscle hypertrophy (muscle growth) and improve endurance by stimulating mitochondrial activity.

Korean Mistletoe having been shown to not only prevent muscle atrophy but also promote hypertrophy is significant because it means that Korean Mistletoe not only prevents muscle breakdown but also increases muscle growth. In studies, mice that were fed Korean Mistletoe for 4 weeks showed increases in muscle mass and grip strength. Researchers indicated multiple factors leading to this result including the AKT/mTOR pathway. The AKT/mTOR pathway is a signaling pathway recognized as the major pathway regulating protein synthesis. Due to the mice showing increases in muscle and greatly increased strength, the researchers determined that Korean Mistletoe is anabolic as it directly leads to larger and stronger muscles. In addition to increases in muscle and strength, the mice also showed incredible increases in endurance and exercise capacity making Korean Mistletoe an ideal option for strength, endurance, and fitness athletes.

Korean Mistletoe has also been shown in studies to increase endurance and decrease fatigue through increasing mitochondrial oxygen consumption and increased expression of PPARy. Notable examples included increases of up to 212% in swim tests on mice and in one test mice being fed Korean Mistletoe extract ran twice as far as their counterparts resulting in an incredible 100% increase in endurance. (Don’t take us wrong here, we are just conveying the study information but do realize that that is far too good to be true for it to directly translate over into humans at the same %’s; but even transferring over at a fraction of the effectiveness could lead to incredible results).

The last study that we want to bring attention to in this write up is related to fat loss. In one 15 week study on mice, two groups were fed a high fat diet with one group also being fed Korean Mistletoe Extract. At the end of the study, the mice fed the Korean Mistletoe Extract were shown to have 20% less bodyfat than the control group. Researchers found that Korean Mistletoe Extract increases thermogenesis and nearly tripled the amount of UCP1 (uncoupling protein 1), a thermogenic molecule related to the burning of subcutaneous and visceral fat.

This is an incredible level of fat burning potential for something so anabolic.

Anabolic Effect provides 2,000 mg. Korean Mistletoe Extract per serving.

Eriobotrya Japonica Extract:

Eriobotrya Japonica contains a variety of natural anabolic components that may be beneficial to those looking to build lean muscle, increase strength, burn fat, & improve endurance and athletic performance. These include some very well-known names such as Epicatechin, Ferulic Acid, Caffeic Acid, Ursolic Acid, Tormenic Acid, Ellagic Acid, and more. Studies have shown Eriobotrya Japonica to increase the expression of certain myogenic genes and also activate the AKT/mTOR pathway and therefore promote muscle protein synthesis and lean muscle gains. In studies, Eriobotrya Japonica has been shown to prevent muscle atrophy (muscle wasting/muscle loss) and to increase muscle hypertrophy (muscle growth) which also makes it ideal for lean muscle retention while dieting.

Rehmannaie Radix Extract:

Rehmannaie Radix has several active compounds may be useful for building lean muscle, strength, and improving endurance, athletic performance, and fat loss. However, the main two we are going to focus on are Catalpol and to a lesser extent, Loganin.

Catalpol has been referred to by some as the closest one can get to natural gene doping due to its effects on erythropoietin (EPO), vascular endothelial growth factor (VEGF), insulin like growth factor type 1 (IGF-1), endorphins, and more.

Erythropoietin (EPO) increases red blood cells which can in turn carry more oxygen to the muscles and lead to increases in overall performance and increases in VO2 max, overall power output, increased endurance, delayed fatigue, improved recovery, and more. These adds give athletes a huge competitive advantage and EPO has been used illegally by athletes for decades to increase performance. It is most commonly associated with cycling because of the high number of cyclists that have been caught using EPO. What if you could naturally increase EPO? Of course, not to the degree that comes with illicit use, but that may still provide noticeable results in improved performance.

Loganin is a lesser known and lesser emphasized constituent of Rehmannaie Radix Extract. However, if Catalpol wasn’t such an extraordinary ingredient, Loganin itself may be an ingredient worth featuring on its own. It is an iridoid glycoside and can be derived from several sources but is present in high quantities in Rehmannaie Radix. Loganin has the potential to be a fascinating anabolic agent in its own right and is currently being studied for muscle atrophy. In addition, Loganin seems to possess anti-inflammatory, antioxidant, glucose lowering, and muscle protective benefits. Loganin is thought to work by upregulating the AKT/mTOR pathway and increasing IGF-1. Loganin has also been shown in animal studies to increase lean muscle, strength, and protein synthesis.

While many of the ingredients in Anabolic Effect may have potent synergistic effects with one another, the combination of Rehmannaie Radix and S7® may be particularly interesting due to Catalpol’s possible effects on EPO and S7® having been shown to increase nitric oxide levels by 230% through stimulating the body’s own natural production of nitric oxide. This could lead to an abundance of oxygen rich red blood cells being pumped through wide open blood vessels to hard working muscles.

PrimaVie® Extract (50% Fulvic Acid):

PrimaVie® is a clinically proven high quality purified extract from the Himalayas that contains 50% Fulvic Acid and over 40 other trace minerals and has been shown in studies to significantly increase free and total testosterone levels, as well as improve physical performance and reduce fatigue. In one human trial, was able to markedly the extracellular matrix gene expression responsible for skeletal muscle adaptation, making it one of the only ingredients to augment the effect of exercise in this manner.

In another study involving 60 infertile men, supplementation was able to improve sperm count by over 60%, improve sperm motility by nearly 40%, and increase levels of testosterone by 23.5% through a reduction inn circulating free radicals. To further back this up, another study involving 75 males demonstrated a 20% increase in total testosterone and a 19% increase in free testosterone.

has been used for centuries in Ayurvedic medicine to support male health, energy, vitality, cognitive health, rejuvenation and more.

ActiGin®:

ActiGin® is a natural patented proprietary sports nutraceutical complex comprised of highly fractionated Panax notoginseng and Rosa roxburghii and created using pharmaceutical grade extraction and processing technology and designed to be a 3 in 1 performance aid focusing on – Energy, Endurance, & Recovery.

ActiGin is the result of more than 10 years of research and is backed by one in-vivo and five human clinical trials and has been clinically shown to increase endurance, VO2 Max, muscular energy (ATP production), and reduce inflammation in muscles.

Studies indicate that ActiGin®’s effects on improving endurance/, energy, and recovery time in high intensity exercises may be due to its ability to preserve insulin receptors and glucose transporters on muscle membranes during intensive exercises to ensure a continuous supply of blood glucose into the muscle. Glucose is the fuel for muscle during intense exercise. Depletion of glucose had detrimental effects on the muscles ability to contract and work properly. There are senescent (deteriorating) cells in all human tissues including short lived endothelial cells (lifespan < 2 weeks) in blood vessels and tissues. ActiGin® substantially reduced senescent cell population (mostly endothelial progenitor cells) of exercising skeletal muscle. Also, high intensity exercise acutely decreases satellite cell numbers due to increased demand on the nucleus for muscle regeneration and ActiGin® completely attenuated acute satellite cell depletion. These findings suggest that ActiGin® effectively facilitates senescent cell clearance in contracting muscles and helps maintain muscle stem cell numbers during exercise to high-intensity endurance performance.

Study Highlights include:

Increased endurance time (time to exhaustion) by 20% (improve VO2 Max).
Increase energy (ATP production) but raising the pace-making Citrate synthase enzyme in the first step of the citric acid cycle by 42%.
Speed recovery by reducing inflammation in muscles as evidenced by the reduction of inflammatory biomarkers (TBARS (24%), MDA (44%), Interleukin 6 (IL-6) (35%), and Creatine kinase (CK) (69%)).
Eliminate senescent (deteriorating) muscle cells through macrophage phagocytosis (macrophage phagocytosis involves cells that protect the body by ingesting harmful particles and dead or dying cells). Specifically decreasing SA-B-gal and collagenase, reverse apoptotic DNA fragmentation and leukocyte infiltration, and increase iNOS and IL-6 mRNA expression in the quadriceps after 60 minutes of cycling at 70% VO2 max.
Effectively facilitating senescent (deteriorating) cell clearance in contracting muscles and helping maintain muscle stem cell numbers during exercise to high-intensity endurance performance.

In short, ActiGin® is designed to help you train harder, long, and recover more effectively.

S7®:

The human body already produces nitric oxide as a vasodilator, signaling the blood vessels to relax, thus increasing blood flow and delivering more oxygen, fuel, and other key nutrients to the muscles.

S7® is a blend of 7 plant-based ingredients that has been clinically shown to increase nitric oxide (NO) levels by 230%. S7® is very unique in that it works differently than other nitric oxide adders on the market by triggering the body to increase its own internal nitric oxide production.

Anabolic Effect contains 50 mg. of S7®, the dosage used in the clinical studies showing the 230% nitric oxide increase.

AstraGin®:

AstraGin® is a natural patented ingredient complex comprised of highly fractionated Astragalus membranaceus and Panax notoginseng and created using pharmaceutical grade extraction and processing technology and designed to help nutrient absorption.

In short, AstraGin® is designed to help make sure you properly absorb the other great nutrients in Anabolic Effect for maximum results.

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